Kwiminyaka esixhenxe ebuyile, abazali bakaYuto Amakawa babhubha kwingozi yemoto, bamshiya yedwa engenanto yodwa eyasala endlwini yakhe, isihlobo esinye siyinto engaqondakaliyo nengafaniyo ayinikwa ngumakhulu wakhe ongasekhoyo. Ukusukela ngelo xesha, umhlobo wakhe wobuntwana uRinko Kuzaki (kunye nabazali bakhe [isahl. 1]) baye bamphekela kwaye bamkhathalela. Xa edibana nenkosikazi yedemon yesamurai, u-Himari ubomi bakhe buthatha ithuba. U-Himari umtyhilela ukuba uninzi lookhokho bakhe babeyinxalenye yeentsapho ezilishumi elinesibini zeDemon Slayer ezazibulala iidemon ngenxa yeminyaka yobukhosi. Ufungile ukuba ukhusele uYuto kwiidemon eziza kumtshabalalisa, kodwa ukungavisisani neekati zaseYuto kwenza kube nzima ukuzinyamekela.
Emva kwexesha, u-Yuto uwa phezu kwabafazi abahlukeneyo abathandayo kuye: Shizuku, imizuchi ngomntwana omncinci; U-Lizlet, i-tsukumogami esebenzisa isicakakazi esithengisa iti; kunye noKuesu, omnye uSimon Slayer otyhilekileyo ukuba abe liqabane likaYuto kunye nendoda evela kwilahleko eyadlulayo.
Njengoko umboniso uqhubeka, iqela kunye no-Yuto bawela kwi-ayakashi eyomeleleyo, kunye nabambalwa babo abangamadlelane, kwaye ekugqibeleni u-Yuto wenza ukhetho oluguqula ubomi ukuze alwe ngenxa yoluvo lwakhe lokuphila phakathi kwe-ayakashi kunye nomntu ngamnye.
